C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/495 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2372119
The present invention relates to a transforming growth factor-beta (TGF- .beta.)-like protein which is derived from neurons and glial cells, and which has a neurotrophic effect on dopaminergic (DAergic) neurons, to nucleic acids coding for the protein, to a vector containing the nucleic acids, to host organisms containing the nucleic acids or the vector, to antibodies directed against the protein, to methods for the production of the nucleic acids, the vector or the protein, to a pharmaceutical composition for the treatment of neurodegenerative disorders in mammals and to a diagnostic kit for the detection of said disorders.
La présente invention concerne une protéine de type facteur-.beta. de croissance transformant (TGF-.beta.) laquelle est dérivée de neurones et de cellules gliales, et laquelle présente un effet neurotrophique sur les neurones dopaminergiques (DAergiques), des acides nucléiques codant pour la protéine, un vecteur contenant les acides nucléiques, des organismes hôtes contenant les acides nucléiques ou le vecteur, des anticorps développés contre la protéine, des méthodes de production des acides nucléiques, du vecteur ou de la protéine, une composition pharmaceutique de traitement de troubles neurodégénératifs chez des mammifères ainsi qu'un matériel de diagnostic destiné à la détection desdits troubles.
Kriegelstein Kerstin
Unsicker Klaus
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum
Moffat & Co.
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