Adp-ribosylating bacterial toxins

Details Adp-ribosylating bacterial toxins Adp-ribosylating bacterial toxins

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 39/02 (2006.01) A61K 39/07 (2006.01) A61K 39/09 (2006.01) A61K 39/095 (2006.01) A61K 39/112 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C07H 21/04 (2006.01) C07K 14/195 (2006.01) C07K 14/22 (2006.01) C07K 14/255 (2006.01) C07K 14/30 (2006.01) C07K 14/315 (2006.01) C07K 14/36 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2442123

ADP-ribosylating toxins from Neisseria meningitidis, Streptomyces coelicolor, Mycoplasma pneumoniae, Salmonella typhimurium, Salmonella paratyphi, and Streptococcus pyogenes are disclosed, together with mutant toxins and uses therefor. There is only a low level of sequence identity between these toxins and toxins such as cholera toxin and E.coli heat labile toxin.

L'invention concerne des toxines ADP-ribosylantes de <i>Neisseria meningitidis, Streptomyces coelicolor, Mycoplasma pneumoniae, Salmonella typhimurium, Salmonella paratyphi</i> et <i>Streptococcus pyogenes</i>, ainsi que des toxines mutantes et des utilisations associées. Ces toxines présentent uniquement un faible niveau d'identité de séquence avec des toxines telles que la toxine du choléra ou la toxine thermolabile <i>E.coli</i>.

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