Polypeptides that bind an anti-tissue factor antibody and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/42 (2006.01) A61K 39/395 (2006.01) C12N 5/00 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) G06F 17/50 (2006.01)

Patent

CA 2526080

The present invention relates to antibodies and polypeptides useful in blocking the binding of antibodies to anti-tissue factor, decreasing the activity of the anti-tissue factor antibodies and/or neutralizing the activity of an anti-tissue factor antibody. The present invention also relates to nucleic acids encoding the antibodies and polypeptides and compositions comprising the antibodies or polypeptides or nucleic acid molecules. The present invention provides methods of treating a hypercoagulable state or an inflammatory disease using the antibodies and polypeptides of this invention and other methods of using said antibodies and polypeptides.

L'invention concerne des anticorps et des polypeptides servant à bloquer la liaison d'anticorps avec un anti-facteur tissulaire, réduire l'activité des anticorps anti-facteur tissulaire et/ou neutraliser l'activité d'un anticorps anti-facteur tissulaire. Cette invention se rapporte en outre à des acides nucléiques codant lesdits anticorps et polypeptides, ainsi qu'à des compositions comprenant ces anticorps ou polypeptides ou molécules d'acide nucléique. La présente invention concerne par ailleurs des procédés permettant de traiter un état d'hypercoagulation ou une maladie inflammatoire au moyen des anticorps et polypeptides selon l'invention, ainsi que d'autres procédés d'utilisation desdits anticorps et polypeptides.

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