Nt-4 neurotrophic factor

Details Nt-4 neurotrophic factor Nt-4 neurotrophic factor

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/385 (2006.01) A61K 49/00 (2006.01) C07H 21/00 (2006.01) C07K 1/16 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092567

A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been ident-ified by PCR amplification of human genomic DNA. Pro-vided herein is nucleic acid encoding NT-4 useful in diag-nostics and in the recombi-nant preparation of NT-4. A1-- so provided herein are nucleic acids encoding naturally oc-curring amino acid sequence variants of NT-4, designated NT-4.beta., NT-4.gamma., and NT-4.DELTA.. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.

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