A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 47/02 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2733778
A pharmaceutical composition is provided which can easily be prepared and which can prevent decomposition of an aminoacetylpyrrolidine carbonitrile derivative, as an effective component, which derivative is in general instable in a pharmaceutical composition. More specifically, the pharmaceutical composition comprises an aminoacetyl pyrrolidine carbonitrile derivative represented by the following general formula (1): (see formula 1) (in the formula (1), A represents CH2, CHF or CF2; and R1 represents a secondary amino group which may have a substituent), and the following components blended with the derivative: (1) a sugar alcohol; (2) calcium carbonate, sodium citrate or sodium sulfate; and (3) a neutral low melting point oily and/or fatty substance.
La présente invention concerne une composition pharmaceutique dans laquelle il est possible dinhiber la dégradation dun dérivé aminoacétylpyrrolidinecarbonitrile (une substance qui devient instable dans une composition pharmaceutique) présent dedans, laquelle composition pharmaceutique pouvant être produite de manière pratique. Cette composition pharmaceutique renferme un dérivé aminoacétylpyrrolidinecarbonitrile représenté par la formule (1) [dans laquelle A représente CH2, CHF ou CF2 ; et R1 représente un groupe amino secondaire qui peut être substitué], (1) un alcool de sucre, (2) du carbonate de calcium, du citrate de sodium ou du sulfate de sodium et (3) une substance neutre à bas point de fusion du type huile et graisse.
No affiliations
Kyorin Pharmaceutical Co. Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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