Regulatory b cells and their uses

Details Regulatory b cells and their uses Regulatory b cells and their uses

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2722184

The present invention relates to a phenotypically distinct CD1d high CD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-IO). The invention also relates to the use of these IL-IO producing regulatory B cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of these regulatory B cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of this subset of regulatory B cells, or inhibition of their IL-IO production can be used to upregulate immunodeficient conditions, and/or to treat tumors/cancer. Diagnostic applications also are encompassed.

La présente invention concerne une sous-population de lymphocytes B  CD1dhighCD5+ phénotypiquement distincts qui régule les réactions inflammatoires médiées par les lymphocytes T par le biais de la sécrétion de linterleukine-10 (IL-1O). Linvention concerne également lutilisation  de ces lymphocytes B régulateurs produisant des IL-1O dans la gestion des réactions immunitaires et inflammatoires, et dans le traitement de maladies. Les approches thérapeutiques impliquant le transfert adoptif de ces lymphocytes B régulateurs, ou lexpansion de leurs taux endogènes pour contrôler les maladies ou affections auto-immunes ou inflammatoires, sont décrites. Lablation de cette sous-population de lymphocytes B régulateurs, ou linhibition de leur production de IL-1O peut être utilisée pour sur-réguler des affections dimmunodéficience, et/ou pour traiter des tumeurs/cancer. Les applications diagnostiques sont également couvertes.

Affiliated with

Also associated with

Rating

Regulatory b cells and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Regulatory b cells and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Regulatory b cells and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1466714