Novel anti-notch3 antibodies and their use in the detection...

Details Novel anti-notch3 antibodies and their use in the detection... Novel anti-notch3 antibodies and their use in the detection...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/12 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2666179

The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.

La présente invention porte sur de nouveaux anticorps qui se lient spécifiquement à Notch 3 humain et sur leur utilisation dans la détection et/ou le diagnostic de maladies apparentées à Notch 3, telles que le cancer. La présente invention comprend également des acides nucléiques codant pour ces nouveaux anticorps, des vecteurs et des lignées cellulaires recevant les acides nucléiques, et des coffrets comprenant les anticorps pour une utilisation dans la détection et le diagnostic.

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