Immunogens for stimulating mucosal immunity

Details Immunogens for stimulating mucosal immunity Immunogens for stimulating mucosal immunity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/108 (2006.01) A61K 39/118 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01) C07K 14/02 (2006.01) C07K 14/16 (2006.01) C07K 14/245 (2006.01) C07K 14/28 (2006.01) C07K 14/295 (2006.01) C12N 15/31 (2006.01) C12N 15/49 (2006.01) C12N 15/51 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2205130

This patent application relates to immunogens for stimulating mucosal immunity to a pathogen capable of infecting its host through contact with mammalian mucosal membranes. In particular, this invention discloses a number of polypeptides and genetic constructs that include a membrane binding polypeptide operably linked to a peptide from a pathogen. Methods are detailed throughout the claims and the specification for introducing these immunogens into a mammal to stimulate mucosal immune responses.

L'invention concerne des immunogènes pour stimuler l'immunité des muqueuses contre un pathogène capable d'infecter un hôte mammifère par contact avec les membranes muqueuses. En particulier, cette invention concerne certains polypeptides et produits de recombinaison génétique contenant un polypetide, se fixant aux membranes en étant liés physiquement à un peptide provenant d'un pathogène. On décrit en détail dans le descriptif et dans les revendications de cette demande de brevet, des procédés permettant d'administrer ces immunogènes à des mammifères pour stimuler la réponse immunitaire au niveau des muqueuses.

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