C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 13/12 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2580981
It is intended to provide highly stable mutants of human IgG4 antibody. These antibodies include: an antibody in which the CH3 domain of human IgG4 is substituted by the CH3 domain of human IgG1 and which shows suppressed aggregate formation; an antibody in which the CH3 domain and the CH2 domain of human IgG4 are substituted respectively by the CH3 domain and he CH2 domain of human IgG1; and an antibody in which arginine at the 409-position indicated by the EU index proposed by Kabat et al. of human IgG4 is substituted by lysine and which shows suppressed aggregate formation
Cette invention concerne des mutants extrêmement stables d'anticorps IgG4 humains. Ces anticorps comprennent : un anticorps dans lequel le domaine CH3 de l'IgG4 humaine est remplacé par le domaine CH3 de l'IgG1 humaine, et qui présente une suppression de la formation d'agrégats ; un anticorps dans lequel le domaine CH3 et le domaine CH2 de l'IgG4 humaine sont remplacés respectivement par le domaine CH3 et le domaine CH2 de l'IgG1 humaine ; et un anticorps dans lequel l'arginine en position 409, mentionnée dans l'index UE proposé par Kabat et al. de l'IgG4 humaine, est remplacée par la lysine, et qui présente une suppression de la formation d'agrégats.
Takahashi Nobuaki
Yoshida Hideaki
Kirin Beer Kabushiki Kaisha
Kyowa Hakko Kirin Co. Ltd.
Smart & Biggar
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