Isolation and use of motoneuronotrophic factors

Details Isolation and use of motoneuronotrophic factors Isolation and use of motoneuronotrophic factors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C12N 15/11 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2267197

The present invention is directed to a family of motoneuronotrophic factors including MNTF1 and MNTF2, which have been shown to have diagnostic and therapeutic applications in mammals. The present invention is also directed to novel DNA sequences which encode motoneuronotrophic factors, including recombinant human MNTF1-F3 [SEQ ID NO:1] and MNTF1-F6 [SEQ ID NO:2], to vectors which contain these novel DNA sequences, to expression systems and associated hosts which contain these novel DNA sequences, and the novel recombinant human NINTF1-F3 [SEQ ID NO:3] and MNTF1-F6 [SEQ ID NO:4] proteins which are produced by the aforementioned expression systems. The present invention is also directed to the use of motoneuronotrophic factors for promoting axonal regeneration, for inhibiting the effects of hereditary motoneuron disease, for minimizing or inhibiting the effects of scar tissue formation, and for accelerating wound healing while concomitantly minimizing or inhibiting the effects of scar tissue and keloid formation.

Famille de facteurs motoneuronotrophiques, y compris MNTF1 et MNTF2, dont on a découvert les applications diagnostiques et thérapeutiques chez des mammifères. On décrit aussi de nouvelles séquences d'ADN qui codent lesdits facteurs, y compris les facteurs humains de recombinaison MNTF1-F3 [numéro d'identification de séquence: 1] et MNTF1-F6 [numéro d'identification de séquence: 2], ainsi que des vecteurs renfermant les séquences en question, des systèmes d'expression et des hôtes associés qui renferment également les mêmes séquences, et les nouvelles protéines humaines de recombinaison MNTF1-F3 [numéro d'identification de séquence: 3] et MNTF1-F6 [numéro d'identification de séquence: 4] produites par les systèmes d'expression susmentionnés. On décrit enfin l'utilisation des facteurs motoneuronotrophiques pour promouvoir la régénérescence axonique, inhiber les effets de la maladie motoneuronale héréditaire, réduire au minimum ou inhiber les effets de la formation de tissus cicatriciels, et accélérer la cicatrisation tout en parvenant simultanément à réduire au minimum ou à inhiber les effets de la formation des tissus cicatriciels et de la chéloïde.

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