Methods and compositions for in vitro targeting

Details Methods and compositions for in vitro targeting Methods and compositions for in vitro targeting

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 1/04 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/52 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12N 15/861 (2006.01) C12N 15/864 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2421191

The present invention concerns methods and comositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.

La présente invention concerne des procédés et des compositions utilisées pour le ciblage <i>in vivo</i> et <i>in vitro</i> ; ainsi qu'un grand nombre de peptides de ciblage dirigés sur des organes, des tissus ou des types de cellules humains. Les peptides sont utilisés pour apporter de manière ciblée des agents thérapeutiques, y compris pour apporter des vecteurs de thérapie génique entre autres. Une nouvelle classe de vecteurs de thérapie génique est présentée. Certains peptides parmi les peptides présentés sont utiles en thérapie pour inhiber l'angiogenèse, inhiber la croissance tumorale, induire l'apoptose, inhiber la gestation ou induire une perte de poids. Des procédés permettant d'identifier de nouveaux peptides de ciblage chez l'homme et permettant d'identifier également des paires récepteur-ligand endogènes sont présentés, de même que des procédés d'identification de nouveaux agents infectieux qui sont la cause d'états pathologiques chez l'homme, et qu'un nouveau mécanisme permettant d'induire l'apoptose.

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