Methods and materials for preparation of modified antibody...

Details Methods and materials for preparation of modified antibody... Methods and materials for preparation of modified antibody...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 1/107 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2507749

Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.

Méthodes d'identification des résidus d'acides aminés d'un domaine variable d'anticorps qui peut être modifié sans diminuer son affinité naturelle pour un antigène tout en réduisant son immunogénicité relativement à une espèce hétérologue, ainsi que de préparation de domaines variables d'anticorps ainsi modifiés en vue de les administrer à des espèces hétérologues. Des régions variables d'anticorps préparées selon ces méthodes sont aussi décrites.

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