C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/437 (2006.01)
Patent
CA 2579221
The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention porte sur des composés représentés par la formule (I) (dans laquelle les variables A1, A2, B, J, K, m, n, R4, R5a, R5b et R5c sont telles que définies dans la description), lesquels composés sont utilisés comme antagonistes de récepteurs CGRP et servent au traitement ou à la prévention de maladies dans lesquelles le peptide CGRP est impliqué, telles que le mal de tête, la migraine et la céphalée vasculaire de Horton. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et compositions pour prévenir ou traiter les maladies dans lesquelles le peptide CGRP est impliqué.
Bell Ian M.
Stump Craig A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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