Carbapenems with naphthosultam derivative linked via methylene

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 477/14 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2298997

The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The napththosultam is further substituted with various substituent groups including at least one cationic group.

Cette invention se rapporte à des agents antibactériens à base de carbapenems, dans lesquels le noyau de carbapenem est substitué dans la position 2 par un naphtosultame lié par un groupe CH¿2?. Le naphtosultame est ensuite substitué par divers groupes substituants, y compris un groupe cationique au moins.

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