C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/12 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61P 39/06 (2006.01) C07D 263/24 (2006.01) C07D 307/24 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2389685
The invention concerns novel heterocyclic derivatives having a calpain inhibiting activity and/or an activity trapping reactive oxygen species, of formula (I) wherein A, X, Y, R?1¿, R?2¿ and Het represent variable groups. The invention also concerns methods for preparing said compounds, pharmaceutical preparations containing them and their therapeutic use, in particular as calpain inhibitors and/or as trapping agents for reactive oxygen species, whether selectively or not.
La présente invention concerne de nouveaux dérivés hétérocycliques présentant une activité inhibitrice des calpaïnes et/ou une activité piégeuse des formes réactives de l'oxygène, de formule (I) dans laquelle A, X, Y, R1, R2 et Het représentent des groupes variables. L'invention concerne également leurs méthodes de préparation, les préparations pharmaceutiques les contenant et leur utilisation à des fins thérapeutiques, en particulier en tant qu'inhibiteurs de calpaïnes et/ou piégeurs de formes réactives de l'oxygène, de manière sélective ou non.
Auvin Serge
Chabrier de Lassauniere Pierre-Etienne
Goudreau Gage Dubuc
Ipsen Pharma S.a.s
Societe de Conseils de Recherches Et D'applications Scientifique
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