Methods and compositions for eliciting an immune response

Details Methods and compositions for eliciting an immune response Methods and compositions for eliciting an immune response

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2406853

The invention provides methods and compositions useful for inducing or enhancing an immune response in a human or non-human animal. In an embodiment, the method involves administering an antigen-presenting cell chemotaxin, such as a chemokine polypeptide or variant thereof, optionally with administration of an antigen. In some embodiments, the chemokine or variant is chemotactic for dendritic cells and/or macrophages, but not chemotactic for one or more of neutrophils, T-lymphocytes, monocytes, or eosinophils. In an embodiment, the chemokine or variant is a chemotaxin for immature but not mature dendritic cells.

L'invention concerne des méthodes et des compositions utilisées pour induire ou améliorer une réponse immunitaire chez un être humain ou un animal. Dans un mode de réalisation, la méthode consiste à administrer une chimiotaxine cellulaire présentant un antigène, tel qu'un polypeptide de la chimiokine ou un variant correspondant, facultativement lors de l'administration d'un antigène. Dans certains modes de réalisation, la chimiokine ou son variant est chimiotactique vis-à-vis de cellules dendritiques et/ou macrophages, mais ne l'est pas vis-à-vis d'au moins un des neutrophiles, des lymphocytes T, des monocytes ou des éosinophiles. Dans un mode de réalisation, la chimiokine ou son variant est une chimiotaxine vis-à-vis de cellules dendritiques immatures mais non matures.

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