Modified globin proteins with altered electron transport...

Details Modified globin proteins with altered electron transport... Modified globin proteins with altered electron transport...

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 9/00 (2006.01) A61K 38/42 (2006.01)

Patent

CA 2690370

The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl haem iron via one or more protein amino acids. The invention provides such proteins that comprise a modification to enhance this pathway.

La présente invention concerne une protéine modifiée porteuse d'oxygène à base de porphyrine, telle qu'une hémoglobine, qui s'est avérée, dans son état non modifié, présenter un site de faible affinité de transfert d'électrons et un transfert d'électrons d'affinité élevée entre un réducteur et du fer ferryl héminique via un ou plusieurs acides aminés protéiques. L'invention concerne de telles protéines qui comprennent une modification visant à améliorer ledit mécanisme.

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