Processes for the preparation of 6- beta-hydroxy morphinan...

Details Processes for the preparation of 6- beta-hydroxy morphinan... Processes for the preparation of 6- beta-hydroxy morphinan...

C - Chemistry, Metallurgy

07

D

C07D 489/02 (2006.01)

Patent

CA 2728083

The invention provides processes for the conversion of a 6-keto morphinan to a 6-hydroxy morphinan. In particular, the invention provides a stereoselective process for the conversion of a 6-keto morphinan to a 6-beta-hydroxy morphinan. The reduction is preferably done by formamide sulfinic acid and in the presence of a protein receptor (i.e. a base) which is added in two portions, second portion after one of the reaction components has precipitated in the solution.

L'invention porte sur des procédés pour la conversion d'un 6-cétomorphinane en un 6-hydroxymorphinane. En particulier, l'invention porte sur un procédé stéréosélectif pour la conversion d'un 6-cétomorphinane en un 6-bêta-hydroxymorphinane. La réduction est, de préférence, réalisée par de l'acide formamide sulfinique et en présence d'un récepteur protéique (à savoir, une base) qui est ajouté en deux fractions, la seconde fraction après que l'un des composants réactionnels a précipité dans la solution.

Affiliated with

Also associated with

Rating

Processes for the preparation of 6- beta-hydroxy morphinan... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Processes for the preparation of 6- beta-hydroxy morphinan..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for the preparation of 6- beta-hydroxy morphinan... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1468370