Acylfulvene analogues as antitumor agents

Details Acylfulvene analogues as antitumor agents Acylfulvene analogues as antitumor agents

C - Chemistry, Metallurgy

07

C

C07C 49/737 (2006.01) A61K 31/12 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) C07C 45/45 (2006.01) C07C 45/46 (2006.01) C07C 45/65 (2006.01) C07C 45/67 (2006.01) C07C 49/67 (2006.01) C07C 49/683 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 49/755 (2006.01) C07C 69/007 (2006.01) C07C 271/12 (2006.01)

Patent

CA 2155329

A method of inhibiting tumor cell growth in a subject is provided comprising contacting the tumor with a therapeutic amount of an acylfulvene analog having structure (I), wherein die analog is capable of inhibiting tumor cell growth without excessive toxicity to the subject and wherein R is (a), where R1= alkyl, aryl, NH2, NHR, or NR2.

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