Highly bioavailable oral delayed release dosage forms of...

Details Highly bioavailable oral delayed release dosage forms of... Highly bioavailable oral delayed release dosage forms of...

A - Human Necessities

61

K

A61K 9/32 (2006.01) A61K 9/50 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2612960

An oral, highly bioavailable unit dosage form of O-desmethylvenlafaxine succinate (DVS) having a delayed release of at least about one hour and a sustained release over multiple hours to provide a total release of greater than about 85 % within about 12 to about 14 hours is described. In one embodiment, the superbioavailable DVS composition has a delayed release of about two hours and a total release of greater than about 95 % within about 12 to about 14 hours. Use of the formulation in treating depression and reducing the gastrointestinal side-effects of O-desmethylvenlafaxine (ODV) is also described.

Formes pharmaceutiques orales hautement biodisponibles à libération retardée, de O-desméthylvenlafaxine succinate (DVS), à libération retardée d'au moins une heure et libération prolongée de plusieurs heures donnant une libération totale supérieure à environ 85 % dans une fourchette d'environ 12 à environ 14 heures. Selon une variante, la composition DVS ultrabiodisponible a une libération retardée d'environ deux heures et une libération totale supérieure à environ 95 % dans une fourchette d'environ 12 à environ 14 heures. Egalement, utilisation de ce type de formulation pour le traitement de la dépression et la réduction des effets secondaires gastro-intestinaux du produit O-desméthylvenlafaxine (ODV).

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