C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 3
Patent
CA 2493923
A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.
L'invention concerne un nouveau gène 191P4D12(b) et sa protéine codée, ainsi que des variants de celle-ci. 191P4D12(b) présente une expression spécifique au tissu dans un tissu adulte normal et s'exprime de manière aberrante dans les cancers énumérés dans le tableau I. En conséquence, 191P4D12(b) fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique relative au cancer. Le gène 191P4D12(b) ou un fragment de celui-ci, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci peuvent servir à obtenir une réponse immunitaire humorale ou cellulaire. On peut également utiliser des anticorps ou des lymphocytes T réactifs au 191P4D12(b) en immunisation active ou passive.
Challita-Eid Pia M.
Faris Mary
Ge Wangmao
Jakobovits Aya
Raitano Arthur B.
Agensys Inc.
Fetherstonhaugh & Co.
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