Interactions of substances with surfaces made from...

G - Physics – 01 – N

Patent

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Details

G01N 33/92 (2006.01) G01N 30/02 (2006.01)

Patent

CA 2326633

The invention relates to the analysis of interactions of substances or materials with surfaces or interfaces made from amphiphilic materials and in particular partition coefficients and/or binding constants are determined. For this purpose use is made of a carrier material, which is so coated with amphiphilic molecules in the so-called fluid phase that the lateral diffusion of the amphiphilic molecules is substantially unimpeded. The invention also relates to a kit suitable for such analyses, and to a process for analyzing these interactions in column chromatography, particularly high pressure or performance liquid chromatography.

L'invention concerne l'analyse d'interactions entre des substances ou des matières et des surfaces ou des surfaces limites constituées de molécules amphiphiles. On détermine des coefficients de répartition et/ou des constantes de liaison. Pour ce faire, on utilise une matière support qui est recouverte de molécules amphiphiles en phase dite fluide de telle façon que les molécules amphiphiles ne soient sensiblement pas gênées dans leur diffusion latérale. L'invention concerne également un kit qui convient à de telles analyses et un procédé d'analyse de ces interactions selon la chromatographie sur colonne, notamment la chromatographie fluide haute pression.

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