Her-2 receptor tyrosine kinase molecules and uses thereof

Details Her-2 receptor tyrosine kinase molecules and uses thereof Her-2 receptor tyrosine kinase molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2481509

The present invention provides HER-2 Receptor Tyrosine Kinase polypeptides and nucleic acid molecules encoding the same. Specifically, the present invention relates to splice variants of HER-2 (HER-2sv). The invention also provides selective binding agents, vectors, host cells, and methods for producing HER- 2sv polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with HER-2sv polypeptides.

L'invention concerne des polypeptides de tyrosine kinase du récepteur HER-2 et des molécules d'acide nucléique codant ceux-ci. L'invention concerne en particulier des variants d'épissage du récepteur HER-2 (HER-2sv). L'invention concerne également des agents de liaison, des vecteurs, des cellules hôtes sélectifs, ainsi que des procédés de production de polypeptides HER-2sv. L'invention concerne en outre des compositions pharmaceutiques et des méthodes de diagnostic, de traitement, d'amélioration, et/ou de prévention de maladies, de troubles et d'états associés aux polypeptides HER-2sv.

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