A human kunitz-type protease inhibitor variant

Details A human kunitz-type protease inhibitor variant A human kunitz-type protease inhibitor variant

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2127249

2127249 9314121 PCTABS00024 Variant of human Kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence X1 Asp Phe Cys Phe Leu Glu Glu Asp X2 Gly X3 Cys X4 X5 X6 X7 X8 X9 Tyr Phe Tyr Asn Asn Gln Thr Lys Gln Cys Glu Arg Phe X10 Tyr Gly Gly Cys X11 X12 X13 Met Asn Asn Phe X14 Thr Leu Glu Glu Cys Lys Asn Ile Cys Glu Asp X15 (SEQ ID No. 1), wherein X1 represents H or 1-5 naturally occurring amino acid residues except Cys, X2-X14 each independently represents a naturally occurring amino acid residue, and X15 represents OH or 1-5 naturally occurring amino acid residues except Cys, with the proviso that at least one of the amino acid residues X1-X15 is different from the corresponding amino acid residue of the native sequence.

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