Methods of making hypermutable cells using pmsr homologs

Details Methods of making hypermutable cells using pmsr homologs Methods of making hypermutable cells using pmsr homologs

C - Chemistry, Metallurgy

12

N

C12N 15/01 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) C40B 50/06 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2476480

Methods of making cells hypermutable are disclosed using PMS2 homologs that have a common sequence motif. The PMS2 homologs of the invention have ATPase- like motifs and are at least about 90% identical to PMS2-134. Methods of generating mutant libraries and using the PMS2 homologs in diagnostic and therapeutic applications for cancer are also disclosed.

La présente invention a trait à de procédés de fabrication de cellules hypermutables utilisant des homologues de PMS2 présentant un motif structural de séquence commun. Les homologues de PMS2 de l'invention présentent des motifs structuraux de type ATPase et sont au moins 90 % identiques au PMS2-134. L'invention concerne également des procédés de génération de bibliothèques de mutants et d'utilisation d'homologues PMS2 dans des applications diagnostiques et thérapeutiques pour le cancer.

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