Stable microbubble suspensions as enhancement agents for...

Details Stable microbubble suspensions as enhancement agents for... Stable microbubble suspensions as enhancement agents for...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Type

Patent

Patent number

CA 2125027

Description

Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01 % wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

Divulgation de suspensions injectables de microbulles de gaz dans un excipient liquide aqueux utilisables comme agents de contraste en échographie par ultrasons. Les suspensions comprennent des composés amphipathiques dont au moins un peut être un phospholipide laminaire comme stabilisant qui empêche les microbulles de se dégonfler au fil du temps et à cause de la pression. La concentration de phospholipides dans l'excipient liquide est inférieure à 0,01 % en poids mais est au moins égale ou supérieure à celle à laquelle les molécules de phospholipides sont présentes uniquement à l'interface microbulles de gaz-liquide. Une méthode est également dévoilée pour préparer les suspensions stables de microbulles d'air ou de gaz.

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