Topical compositions for nsai drug delivery

Details Topical compositions for nsai drug delivery Topical compositions for nsai drug delivery

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 31/192 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2309178

An aqueous pharmaceutical composition of a semi-solid consistency is provided for topical application of non-steroidal anti-inflammatory (NSAI) drugs. The composition comprises one or more NSAI drugs, a non-basic polymeric skin penetration enhancer and a lipophilic solvent. The polymeric skin penetration enhancer is present in an amount sufficient to enhance skin penetration of the NSAI drug. The lipophilic solvent is a mixture of an aliphatic C2 to C8 alcohol and an aliphatic C8 to C30 ester.

L'invention concerne une composition pharmaceutique aqueuse de consistance semi-solide, qui est destinée à l'application topique de médicaments anti-inflammatoires non stéroïdiens (AINS). Cette composition contient un ou plusieurs médicaments AINS, un agent polymère non basique favorisant la pénétration dans la peau et un solvant lipophile. L'agent favorisant la pénétration dans la peau est présent en quantité suffisante pour favoriser la pénétration dans la peau du médicament AINS. Le solvant lipophile est un mélange d'un alcool aliphatique C2-C8 et d'un ester aliphatique C8-C30.

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