Crystal form of asenapine maleate

Details Crystal form of asenapine maleate Crystal form of asenapine maleate

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/407 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2603509

The invention relates to an orthorhombic crystal form of compound trans-5- chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7] oxepino [4,5-c] pyrrole (Z)-2- butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprising an orthorhombic crystal form.

La présente invention concerne une forme cristalline orthorhombique du composé (Z)-2-butènedioate de trans-5-chloro-2,3,3a,12b-tétrahydro-2-méthyl-1H-dibenz[2,3:6,7]oxépino[4,5-c]pyrrole, ainsi que des méthodes de synthèse de cette forme cristalline et des préparations pharmaceutiques comprenant une forme cristalline orthorhombique.

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