Method of reducing or preventing toxicity associated with...

Details Method of reducing or preventing toxicity associated with... Method of reducing or preventing toxicity associated with...

A - Human Necessities

61

K

A61K 31/425 (2006.01) A61K 31/70 (2006.01) A61K 38/06 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2094311

ABSTRACT OF THE DISCLOSURE The present invention provides a method for reducing, or preventing, the toxicity associated with antiretroviral therapy. To this end, when a glutathione intracellular stimulator is administered to a patient receiving antiretroviral therapy, the toxicity associated with such an agent is reduced. In a preferred embodiment, the antiretroviral therapy comprises AZT and DDI. Preferably, the composition for stimulating the intracellular glutathione levels comprises L-2- oxothiazolidine-4-carboxylate. The present invention also provides a method for treating a patient who is HIV positive, or who has AIDS, comprising the step of administering to the patient an antiretroviral therapy and administering to the patient an intracellular glutathione level in a sufficient amount to reduce the toxicity of the antiretroviral therapy.

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