Novel diazabicycloalkane derivatives and their medical use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/08 (2006.01) A61K 31/4995 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2641767

This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro- degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

L'invention concerne des nouveaux dérivés de diaza-bicyclo-alkane dont on a constaté qu'ils étaient des ligands cholinergiques pour les récepteurs nicotiniques de l'acétylcholine et des modulateurs des récepteurs et des véhicules de la monoamine. Compte tenu de leur profil pharmacologique, les composés de l'invention peuvent convenir pour le traitement de maladies et de troubles aussi divers que ceux en rapport avec le système cholinergique du système nerveux central, du système nerveux périphérique, des maladies ou de troubles relatifs à la contraction des muscles lisses, de maladies ou de troubles endocriniens, de maladies ou de troubles en rapport avec la neurodégénérescences ainsi que de maladies ou de troubles en rapport avec une inflammation, une douleur ou des symptômes de sevrage liés à l'arrêt de l'abus de substances chimiques.

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