A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) A61K 31/352 (2006.01) A61K 31/365 (2006.01) A61K 31/366 (2006.01) A61K 31/382 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/41 (2006.01) A61K 31/4353 (2006.01) A61K 31/44 (2006.01) A61K 31/501 (2006.01) A61K 31/5415 (2006.01) A61K 31/55 (2006.01) A61P 3/06 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2442328
The present invention provides therapeutic combinations and methods for treating or preventing a hypercholesterolemia-related or an inflammation- related condition in a subject in need of such treatment or prevention. One therapeutic combination comprises an ASBT inhibitor combined with COX-2 inhibitor. A further therapeutic combination comprises an ASBT inhibitor, a COX-2 inhibitor and an HMG Co-A reductase inhibitor. Another therapeutic combination comprises a chromene COX-2 inhibitor and an HMG Co-A reductase inhibitor.
La présente invention concerne des associations thérapeutiques et des traitements thérapeutiques ou prophylactiques d'états liés à l'hypercholestérolémie ou l'inflammation dans le cas d'un sujet le justifiant. L'une de ces modalités associe pour le traitement un inhibiteur anti-ASBT et un inhibiteur anti-COX-2. Une autre de ces modalités associe un inhibiteur anti-ASBT, un inhibiteur anti-COX-2, et un inhibiteur anti-HMG-Co-A-réductase. Une dernière modalité associe quant à elle un inhibiteur anti-COX-2 à chromène et un inhibiteur anti-HMG-Co-A-réductase.
Isakson Peter C.
Keller Bradley T.
Seibert Karen
Pharmacia Corporation
Sim & Mcburney
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