C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01)
Patent
CA 2742267
The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage using a TEF_beta receptor agonist such as activin A, activin B, activin C, GDF_8, GDF_11 or GDF_15.
La présente invention porte sur des procédés pour favoriser la différenciation de cellules souches pluripotentes. En particulier, la présente invention porte sur un procédé pour augmenter l'expression de marqueurs associés à la lignée endocrine pancréatique à l'aide d'un agoniste du récepteur TEF_bêta tel que l'activine A, l'activine B, l'activine C, GDF_8, GDF_11 ou GDF_15.
Rezania Alireza
Centocor Ortho Biotech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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