C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/34 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/4015 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 17/00 (2006.01) C07C 233/47 (2006.01) C07C 233/51 (2006.01) C07C 233/87 (2006.01) C07C 235/52 (2006.01) C07C 237/22 (2006.01) C07C 259/06 (2006.01) C07D 207/40 (2006.01) C07D 237/22 (2006.01) C07D 277/20 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2418895
The invention concerns compounds of formula (I) wherein: R¿1? represents a radical of formula (a) or (b); Y represents a CH¿2? radical or a sulphur atom; R¿5? represents a hydroxy radical, an alkoxy radical, a NH-OH radical, or a N(R¿8?)(R¿9?) radical; and R¿6? represents an alkyl radical, an OR¿10? radical, a SR¿10? radical, or a (CH¿2?)¿r?-COR¿11? radical. Said compounds are useful as PPAR¿.gamma.? receptor activators in pharmaceutical compositions for use in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and/or diseases related to lipid metabolism), or in cosmetic compositions.
Composés de formule (I) dans laquelle R1 représente un radical de formule (a) ou (b) Y représentant un radical CH2 ou un atome de soufre, R5 représentant un radical hydroxy, un radical alkoxy, un radical NH-OH, ou un radical N(R8)(R9), et R6 représentant un radical alkyle, un radical OR10, un radical SR10, ou un radical (CH2)r-COR11. Ces composés sont utiles comme activateurs des récepteurs de type PPARy, dans des compositions pharmaceutiques destinées à un usage en médecine humaine ou vétérinaire (en dermatologie, ainsi que dans le domaine des maladies cardio-vasculaires, des maladies immunitaires et/ou des maladies liées au métabolisme des lipides), ou bien encore dans des compositions cosmétiques.
Bernardon Jean-Michel
Clary Laurence
Galderma Research & Development
Galderma Research & Development S.n.c.
Robic
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