C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/68 (2006.01) A61K 31/35 (2006.01) C07D 311/70 (2006.01)
Patent
CA 2341353
Disclosed are novel dihydrobenzopyran compounds useful as antiarrhythmic and antifibrillatory agents. The compounds have a structure according to formula (A), or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification. Formula (A) also includes optical isomers, diastereomers or enantiomers. Also disclosed are pharmaceutical compositions and methods of treating disorders and conditions characterized by antiarrhythmic activity using these compounds or the pharmaceutical compositions containing them.
L'invention concerne des composés dihydrobenzopyrannes utiles en tant qu'agents antiarrhytmiques et antifibrillants, ou un amide biohydrolysable, un ester, un imide ou un sel acceptable au plan pharmaceutique. Lesdits composés possèdent une structure de Formule (A) dans laquelle R¿1?, R¿2?, R¿3?, R¿4?, R¿5? sont tels que définis dans la spécification. La formule (A) comprend également des isomères, des diastéréoisomères ou des énantiomères optiques. L'invention porte également sur des compositions pharmaceutiques et des procédés utilisés pour le traitement de troubles et d'états caractérisés par une activité antiarrhythmique, dans lesquels les composés ou compositions pharmaceutiques les contenant sont utilisés.
Kirby Eades Gale Baker
The Procter & Gamble Company
LandOfFree
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