Pyrrolidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 207/09 (2006.01) A61K 31/395 (2006.01) C07D 207/08 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 405/06 (2006.01) C07D 409/02 (2006.01)

Patent

CA 2012295

Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- Image --- (I) and their pharmaceutically acceptable salts, wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; R is -CN or -CONH2; and R is a group of the formula:- Image , Image or "Het" where X and X1 are each independently O or CH2; m is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl.

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