A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/513 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/427 (2006.01) A61K 31/4709 (2006.01) A61K 31/472 (2006.01) A61K 31/496 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2390092
A pharmaceutical composition is disclosed which comprises a soliddispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may op-tionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treating an HIV infection employing said solid dispersion.
L'invention concerne une composition pharmaceutique qui comprend une dispersion solide d'un inhibiteur de la protéase VIH dans un support hydrosoluble, tel que le PEG, présentant des propriétés de biodisponibilité et de dissolution améliorées. La dispersion solide peut éventuellement se présenter sous la forme d'une gélule, d'un comprimé, ou de granulé avec un agent de granulation pharmaceutiquement acceptable. L'invention concerne également des procédés de production de cette dispersion solide et des méthodes de traitement d'une infection par le VIH utilisant ladite dispersion solide.
Fort James J.
Krill Steven L.
Law Devalina
Porter William R.
Qiu Yihong
Abbott Laboratories
Torys Llp
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