Methods for diagnosing and monitoring treatment of lewy body...

A - Human Necessities – 61 – B

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A61B 6/03 (2006.01) A61M 36/00 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2703563

A method of diagnosing Lewy Body Dementia in a human patient by assessing the level of dopamine transporter in at least one region of the patient's central nervous system, where a lowered level of dopamine transporter in the patient is indicative of Lewy Body Dementia. In embodiments of the invention, assessment of dopamine transporter levels includes assessing binding of a dopamine transporter ligand to the dopamine transporters using PET or SPECT.

La présente invention concerne un procédé de diagnostic de la démence à corps de Lewy chez un patient humain par évaluation du niveau de transporteur de la dopamine dans au moins une région du système nerveux central du patient, un niveau réduit de transporteur de la dopamine chez le patient indiquant la démence à corps de Lewy. Dans les modes de réalisation de l'invention, l'évaluation des niveaux de transporteur de la dopamine comprend l'évaluation de la liaison d'un ligand du transporteur de la dopamine aux transporteurs de la dopamine par PET ou par SPECT.

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