Oral pharmaceutical compositions with improved bioavailability

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/48 (2006.01) A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/00 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/36 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/5415 (2006.01) A61K 31/64 (2006.01) A61K 31/675 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 9/14 (2006.01)

Patent

CA 2451377

The present invention relates to prompt-release oral pharmaceutical compositions containing one or more active principles solubilised, suspended or embedded in a suitably formulated amphiphilic matrix for improving in vitro and in vivo bioavailability of medicaments sparingly absorbed through the oral route and/or with problems of high variability of absorption in the gastrointestinal tract.

L'invention concerne des compositions pharmaceutiques orales à libération rapide contenant au moins un principe actif solubilisé, en suspension ou intégré dans une matrice amphiphile formulée de manière appropriée, destiné à améliorer la biodisponibilité in vitro et in vivo de médicaments modérément absorbés par voie orale et/ou qui présentent des problèmes de grande variabilité au niveau de l'absorption par voie gastrointestinale.

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