Inhibition of binding of hox and homeodomain-containing...

Details Inhibition of binding of hox and homeodomain-containing... Inhibition of binding of hox and homeodomain-containing...

A - Human Necessities

61

K

A61K 31/00 (2006.01) C07H 21/04 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2324976

The present invention demonstrates that BMP-2/4 activates osteopontin gene transcription by removing Hoxc-8 binding through Smad1 interaction with the Hoxc-8 DNA binding domain. Since the DNA binding domain is conserved in all Hox and homeodomain-containing proteins, Smad1 likely interacts with all Hox or homeodomain-containing proteins. Furthermore, the present invention reveals the Smad1-mediated transcriptional mechanism in the BMP-2/4 signaling pathway and also provides information about the transcriptional roles of the Hox genes during embryonic development.

La présente invention démontre que la protéine morphogénétique osseuse BMP-2/4 active la transcription du gène d'ostéopontine en enlevant la liaison de Hoxc-8 à travers l'interaction Smad1 avec le domaine de liaison d'ADN de Hoxc-8. Comme le domaine de liaison d'ADN est conservé dans toutes les protéines contenant Hox et des homéodomaines, Smad1 interagit vraisemblablement avec toutes les protéines contenant Hox ou des homéodomaines. En outre, la présente invention dévoile le mécanisme de la transcription régulée par Smad1 dans la voie de signalisation de BMP-2/4; elle fournit également des informations sur les rôles transcriptionnels des gènes Hox pendant le développement embryonnaire.

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