Method for destroying or inhibiting growth of unwanted cells...

Details Method for destroying or inhibiting growth of unwanted cells... Method for destroying or inhibiting growth of unwanted cells...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A01N 43/90 (2006.01) A61K 31/409 (2006.01) A61K 41/00 (2006.01) A61N 5/10 (2006.01)

Patent

CA 2142711

2142711 9404147 PCTABS00030 This invention is a process for the use of a combination of ionizing radiation in conjunction with certain benzoporphyrin derivative compounds (BPD), preferably the compound benzoporphyrin derivative - monoacid ring-A (BPD-MA), to mediate the destruction of diseased or unwanted cells or tissues. Specifically, the invention is a method in which the sensitizer compounds are administered either systemically or locally to the diseased or unwanted tissue and irradiated with ionizing radiation (such as might be produced by a 60Co or x-ray source). The treatment with benzoporphyrin derivative compounds appears to sensitize the target cells or tissues in that those cells do not readily recover from irradiation exposure. In addition, the process may be used to lower the effective amount of radiation applied to a particular tissue target.

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