A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2318498
Coacervates of nucleic acids and a polycationic biopolymer are useful for delivery of genes encoding antigens to mammals. The expression of the antigens in the mammal induces an immune response to the antigen. Furthermore, encapsulation of either or both of the antigen protein and a cytokine enhance the immune response. Selection of cytokines can be used to manipulate the type of immune response which is induced.
L'invention concerne des coacervats d'acides nucléiques et d'un biopolymère polycationique, utiles pour l'administration à des mammifères de gènes codant pour des antigènes. L'expression des antigènes chez le mammifère suscite une réaction immunitaire contre cet antigène. En outre l'encapsulation de la protéine d'antigène ou d'une cytokine, voire des deux, permet de renforcer la réaction immunitaire. Pour manipuler le type de réaction immunitaire induite, on peut opérer une sélection des cyctokines.
August Thomas J.
Leong Kam W.
Truong Vu
Deeth Williams Wall Llp
The Johns Hopkins University
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