Phenylacetamides useful as protein kinase inhibitors

Details Phenylacetamides useful as protein kinase inhibitors Phenylacetamides useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4188 (2006.01) A61P 35/00 (2006.01) C07D 235/06 (2006.01)

Patent

CA 2666116

Compounds of Formula (I) wherein the residues R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, salts thereof; their use, methods of their use, processes for their production, pharmaceutical compositions comprising them, their combinations with second drug substances and the use thereof and the like. The compounds are protein kinase inhibitors and can be used for the treatment of diseases mediated by protein kinase inhibitors, e.g. for the treatment of various proliferative diseases.

L'invention concerne des composés représentés par la formule (I), dans laquelle les résidus R1, R2, R3, R9, R10 et Q, et X, Y et Z sont tels que définis dans la description, des sels de ceux-ci ; leur utilisation, leurs procédés d'utilisation, leurs procédés de production, des compositions pharmaceutiques les comprenant, leur combinaison avec une deuxième substance médicamenteuse et leur utilisation, et similaire. Les composés sont des inhibiteurs de protéine kinase et peuvent être utilisés pour le traitement de maladies favorisées par les inhibiteurs de protéine kinase, par exemple pour le traitement de diverses maladies prolifératives.

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