Composition and methods used during anti-hiv treatment

Details Composition and methods used during anti-hiv treatment Composition and methods used during anti-hiv treatment

A - Human Necessities

61

K

A61K 31/22 (2006.01) A61K 31/675 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2711569

The invention relates to a composition that comprises an anti-HIV treatment and a treatment for the side effects of said anti-HIV treatment for a patient affected by HIV. The invention can particularly be used in the treatment of the side effects generated by certain anti-HIV treatments, such as early aging, lipodystrophy, which can be generated by protease inhibitors or reverse transcriptase inhibitors. The composition of the invention includes at least one inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, at least one inhibitor of farnesyl-pyrophosphate synthase, and at least one anti-HIV agent. One of the methods for treating a patient infected by HIV comprises the following steps in any order: (i) administration of a mixture containing at least one inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase and at least one inhibitor of farnesyl-pyrophosphate synthase; and (ii) administration of an anti-HIV agent, wherein the administrations are concomitant, consecutive, or alternating.

L'invention se rapporte à une composition comportant un traitement anti-VIH et un traitement des effets secondaires de ce traitement anti-VIH chez un patient infecté par le VIH. La présente invention trouve par exemple une application très utile dans le traitement des effets secondaires générés par certains traitements anti-VIH, par exemples le vieillissement précoce, la lipodystrophie qui peuvent être générés par les inhibiteurs de protéase ou les inhibiteurs de la transcriptase inverse. La composition de la présente invention comprend au moins un inhibiteur de l'hydroxyméthylglutaryl-coenzyme A (HMG-CoA) réductase, au moins un inhibiteur de la farnésyl-pyrophosphate synthase, et au moins un agent anti-VIH. Un des procédés de traitement d'un patient infecté par le VIH comprend dans un ordre quelconque les étapes suivantes : (i) administration d'un mélange comprenant au moins un inhibiteur de rhydroxyméthylglutaryl-coenzyme A (HMG-CoA) réductase et au moins un inhibiteur de la farnésyl-pyrophosphate synthase et (ii) administration d'un agent anti-VIH, dans lequel, les administrations sont concomitantes, successives ou alternatives.

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