Protein formulation comprising growth hormone

Details Protein formulation comprising growth hormone Protein formulation comprising growth hormone

A - Human Necessities

61

K

A61K 38/27 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2102693

The invention relates to injectable formulations of growth hormone or any functional analogue thereof, comprising citrate as buffer substance. The formulation could be an aqueous solution of growth hormone or any functional analogue thereof and citrate as buffer substance in a concentration of 2-50 mM. The formulation of the growth hormone or any functional analogue thereof could comprise growth factors, amino acids such as e.g. glycine and alanine and/or mannitol or other sugar alcohols and/or glycerol and/or other carbohydrates and optionally a preservative such as benzyl alcohol. The invention also relates to a process for preparation of the formulation by mixing growth hormone or any functional analogue thereof with citrate as buffer substance or by adding the constituents of the final formulation on the last gel purification step.

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