Dna19355 polypeptide, a tumor necrosis factor homolog

Details Dna19355 polypeptide, a tumor necrosis factor homolog Dna19355 polypeptide, a tumor necrosis factor homolog

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/19 (2006.01) C07K 14/525 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2308365

A tumor necrosis factor homolog, identified as DNA19355, is provied. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.

On décrit un homologue du facteur de nécrose des tumeurs, identifié sous le nom ADN19355. Le polypeptide ADN19355 présente une activité apoptotique dans des cellules cancéreuses de mammifère et peut être impliqué dans des réponses pro-inflammatoires. on décrit également des molécules d'acide nucléique codant ADN19355, des molécules chimères et des anticorps dirigés contre ADN19355.

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