Methods of treating autoimmune diseases using il-21

A - Human Necessities – 61 – K

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A61K 38/20 (2006.01)

Patent

CA 2538083

Administration of IL-21 results in decreasing autoimmune responses and thereby provides a beneficial treatment for autoimmune diseases. Specific autoimmune diseases that may be treated include multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, ankylosing spondilitis, scleroderma, Type I diabetes, psoriatic arthritis, osteoarthritis, inflammatory bowel disease, atopic dermatitis and asthma. Pharmaceutical compositions can include IL-21 polypeptides and active fragments thereof.

La présente invention a trait à l'administration de l'interleukine-21 entraînant une réduction des réponses immunitaires fournissant ainsi un traitement bénéfique pour des maladies auto-immunes. Des maladies auto-immunes spécifiques qui peuvent être traitées comprennent la sclérose en plaques, la polyarthrite rhumatoïde, le lupus érythémateux systémique, le psoriasis, la spondylite ankylosante, la sclérodermie, le diabète de type 1, l'arthrite psoriasique, l'arthrose, la maladie intestinale inflammatoire, la dermatite atopique et l'asthme. L'invention a également trait à des compositions pharmaceutiques comportant des polypeptides de l'interleukine-21 et des fragments actifs de ceux-ci.

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