Designs of labels for detection with a surface-selective...

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G01N 33/00 (2006.01) B22F 3/26 (2006.01) B22F 7/04 (2006.01) B32B 5/16 (2006.01) C01G 49/08 (2006.01) G01N 27/447 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01) G02F 1/35 (2006.01) G02F 1/37 (2006.01)

Patent

CA 2439542

Second harmonic, sum and difference frequency generation can be used to detect a variety of processes, which are otherwise undetectable, using nonlinear- active labels. The labels must have as high a hyperpolarizability as possible. Several designs for large hyperpolarizability second-harmonic active labels are described herein. These labels can be attached to any target molecule or particle, resulting in more highly nonlinear-optically active targets.

Selon cette invention, la génération d'une fréquence deuxième harmonique, d'une fréquence somme et d'une fréquence différence peut être utilisée pour détecter différents processus, sinon indétectables, à l'aide de marqueurs actifs non linéaires. Ces marqueurs doivent présenter une hyperpolarisabilité aussi élevée que possible. Plusieurs conceptions de grands marqueurs actifs de deuxième harmonique à hyperpolarisabilité sont décrites dans cette invention. Ces marqueurs peuvent être fixés à n'importe quelle molécule cible ou particule cible, ce qui a pour résultat l'obtention de cibles plus actives au niveau optique non linéaire.

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