Anti-muscarinic agent and estrogen-agonist for treating...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/135 (2006.01) A61K 9/00 (2006.01) A61K 31/137 (2006.01) A61K 31/565 (2006.01) A61K 31/568 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2466336

The invention relates to a method of treating unstable or overactive urinary bladder, wherein the method comprises administering to a patient in need of such treatment an antimuscarinic agent in a pharmaceutically effective amount thereof and ostrogen agonist in a pharmaceutically effective amount thereof. The antimuscarinic agent is preferebly tolterodine or a tolterodine-related compound. The invention also relates to a pharmaceutical formation containing an antimuscarinic agent, estrogen agonist and pharmaceutically excipients and the use of the combination for the manufacture of a therapeutical formulation for treating unstable or overactive urinary bladder.

Procédé destiné à traiter une vessie instable ou hyperactive, qui consiste à administrer à un patient nécessitant un tel traitement un agent anti-muscarinique dans une quantité efficace sur le plan pharmaceutique et un agoniste d'oestrogènes dans une quantité efficace sur le plan pharmaceutique. L'agent anti-muscarinique est de préférence de la toltérodine ou un composé apparenté à la toltérodine. La présente invention concerne également une composition pharmaceutique contenant un agent anti-muscarinique, un agoniste d'oestrogènes et des excipients pharmaceutiquement compatibles, ainsi que l'utilisation de cette composition pour la fabrication d'un produit pharmaceutique destiné à traiter la vessie instable ou hyperactive.

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