Novel benzoimidazole derivatives useful as antiproliferative...

Details Novel benzoimidazole derivatives useful as antiproliferative... Novel benzoimidazole derivatives useful as antiproliferative...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2495577

The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.

L'invention concerne des composés représentés par la formule 1 et des sels, des promédicaments et des solvates pharmaceutiquement acceptables de ces composés, R?1¿, R?2¿, R?3¿ et R?4¿ étant tels que définis dans le descriptif. L'invention concerne également des méthodes permettant de traiter la croissance cellulaire anormale, telle que le cancer chez les mammifères par l'administration des composés représentés par la formule 1, ainsi que des compositions pharmaceutiques contenant les composés représentés par la formule 1, qui permettent de traiter de tels troubles. L'invention concerne en outre des procédés permettant de préparer les composés représentés par la formule 1.

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