Variable region within fibroblast growth factor receptors...

Details Variable region within fibroblast growth factor receptors... Variable region within fibroblast growth factor receptors...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/18 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2083778

A B S T R A C T Regions within the extracellular portions of a fibroblast growth factor receptor (FGFR) confer ligand specificity of the receptor. One such ligand specificity region (LSR) is included in the C-terminal region of the third immunoglobulin like domain of the FGFR and another in the second immunoglobulin like domain. By removing the LSR from an FGFR and replacing it with a corresponding LSR from another FGFR, a chimeric protein is obtained which can bind a ligand with a specificity of binding being determined by the inserted LSR.

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